Minggu, 30 November 2014

Article : Radioactive Appearance toward Human Biological Aspect

hi palls, today i just want to sing another song (share) with you all about my composition. I made it when i was the 3th grade of senior high school, and it was my Final Assignment for Advanced Student at Foreign Language Development Institute (FLDI) Nurul Jadid. so, just check it out,.

RADIOACTIVE APPEARENCE TOWARD
HUMAN BIOLOGICAL ASPECT

ABSTRACT

In this study, the writer analyzes deeply about radioactive appearence toward human biological aspect, where it explain about the usage of radioactive itself. The writer used library research methodology where it specifically describes more about radioactive appearence toward human biological aspect especially with the more adptive substance with mostly people understanding. Likewise, the instrument used is conducting reading books, asking to teacher and browsing to find out more clearly about the problem mentioned. Radioactive appearence really gives some imcact to human biological aspect, either negative or positive impact. Human biological aspect, means it is including into human body, health, and some organ in human. This final project purpose is to inform everyone, especially people who are lack of information about the usage of chemical substance, especially radioactive.
            Factually, most people in this world has wrong assumption that all chemical substances are danger, whereas sometimes the food they consume also contains of chemicel substance. Factually, everything they encounter in their daily contains of some radioactive material, such as; the water they drink the food they consume, the air they breathe, the ground they walk upon, and the costumer products they purchase and use. Although they might be familiar with the use of radiation to diagnose disease and treated cancer, unfortunately when most people hear the term of “radiation” or “radioactive” tend to think of mushroom clouds and mutants that inhabit the world of science fiction movies and comic books, or they directly remember about nuclear.
            In the whole of all,
Radioactive is a chemical substance that is really useful for every aspect in life, such as agriculture, industry, biological especially human biological aspect .With radioactive, human is able to know the condition, function of an organ in people body.
Key words         : Radioactive and Human Biological Aspect



CHAPTER I
INTRODUCTION

A.    Background of Study
In arrow of development that changed annually, everything has developed quickly, such technology. At the same time, the development of disease is also developed very fast, unfortunately human cannot changed their thought and habit. Due to the fact, when many people do not care about their action that can give impact to their biological aspect, however the cause of all is from human being itself who cannot keep their environment well. Besides, human cannot keep their health, for example they never care about the food they consume. Mostly people in this world think that all food is beneficial. On the other hand, when they know about chemical substance, they directly avoid that substance, because they have a perception that all chemical substance is dangerous. Whereas, the food they consume also contains of chemical substance, such radioactive.
Factually, everything they encounter in their daily contains of some radioactive material, such as; the water they drink the food they consume, the air they breathe, the ground they walk upon, and the costumer products they purchase and use. Although they might be familiar with the use of radiation to diagnose disease and treated cancer, unfortunately when most people hear the term of “radiation” or “radioactive” tend to think of mushroom clouds and mutants that inhabit the world of science fiction movies and comic books, or they directly remember about nuclear. When people think that, means they misunderstand about that. Generally, radioactive has been common for human daily, but they do not know about the function of radioactive itself. So what should be human biological aspect? Because biological aspect is the most important aspect for our life, human biological aspect means, it is related to human body, health, food, and so on.
 Radioactive is a chemical substance which always radiate radioactive-ray, and it has positron, electron, proton, Alfa-ray (α), Beta-ray (β), Gamma-ray (γ). Generally, those substances are in unstable condition, so it can give impact and effect for everything that gets those radiations, for example it can break people cell easily. Factually, the capability of bomb atom to have a great energy is not far from radioactive substance that consists in atom itself. On the other case, radioactive appearance gives some benefits for human life. Due to the fact, when many danger diseases human isable to diagnose those diseases with the use of x-ray that consists of radioactive.[1]

B.     Problem of Study
            The writer wants the readers to this scientific writing project who to talk about. Therefore, regarding to the background issue that create concerned understanding of the readers, so it is important to determine the problem of study as follows;
1.      What is radioactive?
2.      What is the correlation between radioactive and human biological aspect?
3.      How does radioactive works in human biological aspect?
4.      What are the disadvantages of radioactive?

C.    Purpose of  Study
            It is easier that the writer is extremely enthusiastic to give some purpose of study to have good relation between the writer and readers. In order to have better discussion needs to mix a specific purpose of study. It will be in some following points as;
1.      To inform about chemical substance, especially radioactive
2.      To know how radioactive works in human biological aspect
3.      To know the impact of radioactive

D.    Key Term of Study
Radioactive and human biological aspect

CHAPTER II
DISCUSSION

A.    Definition of Radioactive
Atom is the smallest particle in a substance, atom in a substance is consisted of proton, electron, and proton. Some substances are arranged for more than one atom that has different mass number, but the atomic number is same. On contrary, if a type of substance with a same atomic number, but different mass number is called isotope, such as hydrogen which has 3 isotopes, those are; H-1, H-2, H-3. So, what is the difference of those isotopes? Proteome (H-1) has 1 proton and 1 electron, it has no neutron, Deuterium (H-2) has 1 proton, 1 electron, and 1 neutron, Tritium (H-3) has 1 proton, 2 neutrons, and 1 electron. Means, the similarity of those hydrogen isotopes is at the number of neutron. Isotopes have a same electron number.[2]
So, what about radioactive? Radioactive emit ionizing particles of various kinds and energies. Generally, beta and gamma radioactive can be used in biological work. It is possible to use two tracers simultaneously and identify each separately. One of those is beta radioactive and the other one is gamma radioactive. Beta rays can be easily screened out with a thin layer of leading to reach the counter selectively. The amount of radioactive material that can be prepared in a single bombardment in the pile varies considerably. Photospheres are one of the highest totally radioactivity 500 mill curies are available in a single unit quality. Onemill curries is equivalent to 3.7 x 1010 disintegrations per second. The approximate specific activity (mill curries per gram) on which the biologically important, elements are available. For biological purposes hose elements which have half-lives or iron one to several weeks are easiest to use. If the half-lives of iron one to several weeks are easiest to use. If the half-lives is longer than the number of disintegration per second is less and detection becomes more difficult, while if the half-lives is shorter intensity more difficult of disintegration is higher but the useful duration of radioactivity is shorter. As the presence of the radioelement is detected by the ionizing radiations that accompany disintegration would be desirable to have high activity over in extend period. However, these two characteristics do not occur together. This is best exemplified by radiocarbon.
Atom consists of nucleus and some electrons that revolve around it. Incineration reaction is just about the changed in orbital atom, especially in the first orbital only, but it does not bother the nucleus. A reaction that is about the changed in nucleus is called nuclear reaction. Nuclear reaction happens in two manners those are; spontaneous and artificial, spontaneous happens to nucleus which is not stable. A substance that consists of unstable substance is called radioactive substance. On the other hand, artificial reaction happens to every stable nucleus.
In 1895, Wilhelm Conrad Rontgen invented cathode rays retort produce a radiation that has high perforate capacity that can blacken photograph film. Although it was covered by carbon paper, at first this ray named x-ray. The fact, x-ray is an electromagnetic radiation that emerge because a high speed impact that cathode rays with anode. Now a day, x-ray is called roentgen ray and used for roentgen to diagnose inside part of human body. The invention of x-ray interested Henry Becquerel to observe a flourencensial substance which can radiate after it got radiation. Becquerel observed that rays radiate from that substance such as x-ray. At the same time, Becquerel examined uranium. theity more difficult of disintegration is higher lt, while the half money adioactive. beta tracessuch as; number is ameUnfortunately, that hypothesis was right that uranium radiation is able to blacken photograph film which is still covered by carbon paper. In the contrary, Becquerel invented that uranium radiates high perforate capacity by itself or without any radiating before it was at the first week of March 1896. A spontaneous radiation is called radioactivity, and a substance that has radioactive characteristics is called radioactive substance. The first radioactive substance invented was uranium then,in 1898 Mari Curie and the husband Pierre Curie invented two substances which are more active than uranium those are Polonium and Radium. Basically, many substances have radioactive character naturally.All isotopes that have atomic number upon 83 have radioactive characters. Substances that have atomic number 83 or less have stable isotope,exceptTechnetium and Paramecium.  Isotopes that have radioactive character are called Radioactive or radio isotope, meanwhile isotope that is non-radioactive is called stable isotope. This full age, radioisotopescan also make from stable isotope. In 1903, Ernest Rutherford interposes that radiation one that emitted by radioactive substance can be differentiated for two type base on its content.  Proton radiationis denominated by alpha ray whileelectron is denominated by named beta ray.  Hereafter Paul U. Villard invented the third ray that has no content is called gamma ray.[3]
Radioactive is an emitting facet of energy, because the disintegration of nucleus. Radioactive substance is used in some therapy as the random to diagnose and assassinate cancer cell. According to James Edge Park 1897, radioactive substance is every substance that emits pengion radiation with an activity more than 70 kBq/kg or 2 nCi/g (seventy kilo Becquerel per kilogram or two Nano curie per gram). Amount 70 kBq/kg (2nCi/g) is the first postulate for a substance is called radioactive, generally is decided based on the determinate from International Atomic Energy Agency. Unfortunately, several substances do not have activity lower than the boundary is considered as radioactive substance, because it cannot be determined for all substances in the light of the character in each substance.

B. The Definition of Human Biological Aspect
Biology is a knowledge studies about physiological aspect in life, the term of“biology” is gotten from Dutch “Biologie” that is from two words of Greek,”bios” (alive) and “logos” (knowledge). The objects of biology are many and one of those is human that usually called as human biological aspect. Some branch of biology study specifically to each organism, such as; botany (plant knowledge), zoology (animal knowledge), microbiology (microorganism knowledge). The difference and grouping is based on the physiological character of organism studied as systematic in encompassing taxonomy and pale biology.[4]
Several aspect of life is investigated in biology, physiological character is studied in anatomy and morphology, in the temporary the function is studied in physiology. Anima’s behavior is studied in etiology. The development of living thing in long time frame is studied in evolution, while the growth and development in life cycle is studied in the development of biology. The interaction between each living thing with the surrounding is studied in ecology; the mechanism of inheriting character that is useful to keep on efficiency of life is studied in genetic.
Nowadays, the development of biological aspect also study about the evolution of living thing in the next era, and the possibility of human being in other planet except earth, is called astrobiology. In the temporary, technology development enable to study in constituent molecule of organism in biology molecular or biochemistry, which is supported by computation technique development in bioinformatics side. Biology is developed quickly in  century, when scientist invented that organism has fundamental characteristics is studied at school and university all over the world.
Means, human biological aspect is an aspect where it is related to human physiological character, such as the condition of the organ, the function of the organ, and the health of the organ.

C.The Correlation of Radioactive and Human Biological Aspect
The  ionizing  radiations  emitted  by  the radioactive  isotopes  are  the  secret  of their  usefulness,  but  at  the  same  time, those  are  also  a  potential  health  hazard to  the  user  and  are  to  be  treated  with danger ill one wishes  to  continue  in  the field.  It  is  true  that  much  important work  can  be  done  without  exceeding the  tolerance  range  set  down  by  the health  physicists  as  the  quantities  of radioactive  materials  employed  are often  considerably  below  that  which may  be  regarded  as a  therapeutic  dose. Nevertheless anycompetent biologist knows that when an ionizing radiation or his genes.  There  is  the possibility  of  ion  formation,  or  fragmentation,  of  the  gene  molecules.Mutations are  known  to  be  possible  as  a  result  of direct  radiation  ofhereditary  material. Since  by  experiment  we  have  learned that  such  mutations  are predominantly deleterious we look upon unnecessary expos as  undesirable.  However,  as undesirable  as it  may  be  to  expose one- self  to  ionizing  radiations  it  is  impossible  entirely  to  escape  them.  Cosmic rays  constant UV bombard  the  earth  with energies  of  the  correct  magnitude  to convert  carbon  atoms  into  radioactive isotopes  whichthe case or organisms.  Are then in place in the {issues.   is  estimated  that  many  thousands  of radioactive  carbon  atoms  already  exist in  each  human  body.  Also,  there  are other  radioactive  materials,  such  as  radioactive  gases  and  other  radioactive contaminants  of  the uranium phoriumsettles,  present  everywhere  to  be  unescapably  accumulated.  The  general  cosmic  ray  and  radionthoron  background results  in  an  exposure  of  approximately C.0001  r.  per B-hour day. For those  engaged  in  the handling of radioactive  materials  it  is  desirable  to know  the  safe  tolerance  levels  for  many  kinds  of  radiation.  The followingstandards have been set:
1.      X and gamma radiation: 200 mr per day (International Congress of Radiobiology in 1934)
2.      X  and gamma radiation: 100  mr  per day  (American  Advisory  Committee  on  x-ray  and  Radium  protector)
3.      X and gamma radiation: 100  mr  per day (Clinton National  Laboratories, Oak  Ridge, Tennessee)
4.      Beta radiation:  100 mr  e. p.  (Clinton National Laboratories)
            The  roentgen  is  declined  in  terms  of the  absorption  of  secondary  electron energy  produced  in  air  by  x  and  gamma radiation.  For  biological  effects  it  became  necessary  to  convert  this  standard to  energies  absorbed  by  tissue  and squinty  an  equivalent  unit,  the  r.  e. p. (roentgen equivalentPhysical) was pro- posed.  It  is an  intensity  of  radiation  such that  it  may  be  absorbed  at  the  rate  of 83  ergs  per  gram  of  tissue.  One r. e. p. becomes a roentgen radiation is X or gamma and absorption takes place in air. An  alternate  definition  is  the dose  of  radiation  which  produces  1.615 x  l0l2 ion  pairs per gram of  air  (in  a microscopically  small  area  at  the  site concerned). It  is generallyconsidered asa dos- age of  100  mr/day  for  several  years will not  produce  visible  damage  to man. But, as  dosage  to  hereditary  mechanism  is additive  or  cumulative  it  may  be  undesirable  to  receive  this  exposure  for  an extendedperiod. There are some evidences. According  to Morgan'  who  in  turn  refers to  unpublished  work  by  E. Lorenzt and L.  O.  Jacobson  that  a  male  (human) should  not  receive  during  his  lifetime an  accumulated  total  body  dose  in  excess of  1,000 roentgens. The maximum  body  dose for  a male  is placed  at  1,000  roentgens  because at  this level  injury  may  approach  that  inflicted by  other  excesses,  i.e.,  smoking,  drinking,  etc.  Quoting  the  same authors  there is  evidence  from  animal  experiments  to "indicate  that  the  ovary  is  one  of  the most  sensitive  body  organs  to  radiation  and  that  there  may  be  an  increased incidence  of  ovarian  tumors  beginning with  an  accumulated dose of  100 roentgens of  total  body  radiation." There  is  almost  universal  agreement among  the workers  in  the  field  of  health physics  that  the  .fiber  electronscope  is the  one  most  practical  instrument  for overall  "health"  monitoring..  It is very sturdy and maintains its calibration. Itis also the cheapest instrument, and  in many  laboratories  it  is  used  for  quantitative  radioactive  measurement  in  tracer experiments.
While  handling  isotopes in  the  volatile  state extreme  precautions  are necessary,  for  fixation,  by  breathing  or  otherwise,  of  one  ten-millionth  of  a  crude of, X.ZMo.e." (Director, of HealthPhysicsDivision, Clinton NationalLabor) Chem. &EnC.  News 25(51):394-398.  19,1. a  long  lived  alpha  emitter  in  the  body, may  approach  fatality.  Alpha  emitters are  not  yet  released  by  the  U.S.A.E.C. for  tracework,  but  this  may  serve  as a  caution  for  those using  beta  and  gam- ma  emmitters. Considerable  attention  should  begin  or  the  design  of  a  laboratory  in which  radioactive  materials  will  be handled.  Experience Mill shows  that  several  rooms  should  be  available;  i.e., one containing  a  good  hood  and  used  for preparation  of  isotopes  for  use;  a  second  room,  in  plant  work  a  greenhouse, in  which  isotopes are  applied  to  the  experimental  material;  a  third  room,  or part  of  the first  room,  should  be  de- voted  to  the  preparation  of  the  materials  for  "counting"  and  a  separate room  should  house  the  radioactive  assay or  "counting”  equipment.  This  seems necessary  if  one  is  to  continue  working  in  this  field  or  an  extended period.  Absolute  cleanliness  is  essential 1or  it  may  be  that  accumulation  of  radioactive  contaminations  will  ruin  experiments before they  become  a  serious health  menace. Operationsof dilution and otherhandling of  radioisotopes  should  be  carried  out  on  metal  (preferably  stainless steel)  trays  in  which  absorbent  material  has been placed. Pipettes  (rubber bulb  type)  and  curved  pipettes  should be  used  in  order  to  avoid  direct  exposure  to  solutions  being  pipetted, Stainless steel or  soapstone sinks  in  good repair  should  be  used.  It  is  the  practice never  to  dispose  of,  via  the  sink,  any materials  which  are  significantly  richer  in  radioactivity  than  the  general background. For other material burial grounds, removed from water supplies,other refuse, etc. are recommended. Waste  materials  of  short  hall-life  may be  accumulated  and  stored  in  a protected place  until  activity  is  dissipated.  It  is the  obligation  of  all  users  of  radioisotopes  proof  of  competence  in handling  isotopes  and  evidence  of knowledge  of  protective  measures.  In fact,  each  institution  contemplating  use or  materials  or  equipment  emitting  any of  the  damaging  radiations  should  have difficulties  involved  in  the  use  of radiocarbon  (C1a).  Special  equipment for  handling  this  isotope  is  in  the  process  of  development  in  a number  of  laboratories,  but  none  is  available  at  the present. The  particular  peculiarities  of  each radioelement  create  minor  problems  in dipleationmeasurement, but  since the  physical  principles  involved  in  the detection  of  ionizing  radiations  are  well understood  it  is  merely  a  problem  of bending  existing  facts 10  lit  special cases. The  number  of  radioactive  isotopes now  available  through  the  Isotopes  Division  of  the  U.S.A.E.C.  Number over a hundred.  A  current  catalogue  of  available  isotopes  is  maintained, giving  the half-life,  the  nature  and  energy  of  the ionizing  radiation,  the  nature  and  size of  the  target  material,.  the  mill curies  of activity  in  the  irradiated  sample,  the specific  activity,  and  the  price. This is a glorious achievement.  The vision and  careful  planning of  those in the  policy  making  division  of  the  U.S. A.E.C.  have  provided  the  American scientist  with  golden  opportunities, usually  well  in  advance of his  immediate needs.  The  stimulating  effects  of  these newly  openedhodzons  in  research technique,  coupled  with  the  achievement  in production  of  radioactive  isotopes  has created  almost  unlimited  opportunities and  consequently  released  a  veritable .  ooooIresearch acylfrite . The  only  barriers  to  opportunity  in this  field  are  training  in  proper  usage o  radioactive materials.  training  in health  protection,  and  the  necessary space,  materials,  and  time  for  work. In  general,  it  can  be  said  that  reception of  "atomic  energy"  and  its  ramification has  been  unusually  well  appreciated and  understood,  thanks  to  the  lore sight of  its  creators.  There  has  been  immediate  adoption  and  absorption  by  biological with the  most  gratifying  pre- laminar  results.  In  dollars  and  cents  a S240,000,000  increase  in  the  annual  out- put  of  American  farms,  which  is  not  an impassible  goal, will  be  a  great  inducementfor  the  use of  radioactive  isotopes to enrich  the American way.
D.    Radioactive Works In Human Biological Apspect
            Radioisotope is used for tracer and radiation source, in this essay the writer is going to discuss about two usage of radioisotope those are for tracer and radiation source. The usage of radioisotope as tracer is based on knot that radioisotope has chemistry character as a stable isotope, so radioisotope gets chemistry reaction as stable isotope. On the contrary, the usage of radioisotope as radiation source is based on the fact that radiation which produces radioactive substance can impact material or creature. Radiation is used for giving physical effect: chemistry, and biology.
The first usage of radiation in human biological aspect is used since last  time, when mostly doctors in Europe and America interested in Wilhelm Conrad Roentgen  that clarified the usage of x-ray is made film picture of bone or skullbonepeople. That is really interesting because the condition of bone or head skull patient that can be observed and studied correctly for diagnosing. Besides, the usage of radiation effect for recovering has been proven by some doctors, such as:
·         In 1897, L Freund was success to lose abiation in people skin with radiating manner.
·         In 1899, J.T Steinbek and T.A.V Siorgein were success to cure skin tumor in patient nose with radiating manner.
From several report about the successes, but some of those are also about the impact after radiated. Some impacts of that are:
·         Is occurring skin reyhema, is such a reddish symptom in patient skin after getting therapy with x-ray
·         Is a occurring of hair split after radiated was reported by J.Daniels in 1896.
According to Dr. James E. Parks, radiation is able to impede the processing of cell fission which can create bereft of cell and the network when obstruction is occurring continuously. As the matter of fact, cancer network or cell has higher capacity fission the cell than human cell which is health. Therefore, based on Tribondau law, cancer cell character is more radiosensitive than usual cell which is health, means cancer and tumor cell can be cured with radiation and radiovaksin. Radiation can enervate microorganism or disease that can be made as vaksin from each disease. One of the examples is radiovaksin for sleeping disease in Africa.[5]
Based on the radioactivity an atom can be detected in network or a part of body, many kinds of information about diagnosing. The result of census taking a network radioactivity or organ after being radiated looks well in scale or digital number existed in census tools. Besides, a substance or compound is able to give an illustration about a network or organ is being observed, because there will be the difference between a health organ and unhealthy organ. It is caused by the difference of metabolism and accumulation degree compound radioactive from the organ or network itself.
Many kinds of radioisotope used as tracer to diagnose some diseases, such as; technetium (Tc-99), talcum (Ti-201), iodine (I-131), natrium (Na-24), xenon (Xe-133), and besi (Fe-59). Tc-99 injected to blood vessel then unhealthy network will pervade in an organ, such as; heart, liver, and lungs, than Ti-201 will be pervaded by health network in heart, therefore both isotopes can be used together to diagnose heart dental. On the other contrary, iodine (I-131) is pervaded by thyroid gland, heart, and some network in brain, so it is used to detect the dental of thyroid gland, heart, and brain tumor. Salt solution consists of Na-24 injected to blood vessel to detect circulation of blood interference with gamma rays radiated from natrium itself. Xe-133 is used to detect lungs disease, P-32 to detect sour eyes, tumor, and liver, Fe-59 is able to detect the formation of eritrosite. Nevertheless, radioisotope is used to diagnose some diseases is also used for thyroid gland cancer therapy. Some radioactive substances have biological and chemical character seems other substance, such as; Radiostronsium-99.[6]
I-131 is accumulated to thyroid gland, people are able to know the function of it whether it is normal or abnormal. According to A Level of Chemistry book created by Charles F Barnaby page 143, compound etilendiamintetra acid (AEDT, EDTA) include tokhelat compound that is eskers out of the body by kidney. While AEDT compound (Cr-51) injected to people body, there will be the information about the function of the kidney itself. On the other hand, Na-24 can detect the circulation of blood, so while Na-24 injected to people body is able to know the condition of the kidney is normal or not.
With radioisotope Na-24, circulation in our body is controlled, when NaCl-24 injected in our body people are able to know the spreading to all blood vessel. In an area where the blood circulation does not have trouble, the digital value is high enough.Than, in area consist of constriction of blood vessel the v digital values is relative low, or occur some troubles in blood circulation. This diagnose also determines the location of blood vessel constriction.
With the assistance of radio pharmacy as carving of organ or network, people are able to know the condition of an organ or network, exist of difference on some organ or network which is unhealthy, such as:
·         The location of cancer in brain
The existence and the location of cancer in people brain can be detected from the result of the inlaid work after injecting patient with carving substance of brain compound perteknetat-99m (Tc-04).
·         The location of cancer in liver
`     The existence and the location of cancer in people brain can be detected from the result of the inlaid work after injecting patient with carving substance of liver mickrokoloid (Tc-99m).
·         The location of cancer in bone
The existence and the location of cancer in people brain can be detected from the result of the inlaid work after injecting patient with carving substance of bone metildifosfonat (MDT-Tc 99m).
·         The location of tumor in kidney
The existence and location of tumor in abnormal network kidney can be detected from the result of the inlaid work after injecting patient with carving substance of bone etilendiamintetra Acid technetium-99m or 99m AEDT.
·         Determine eritrosit age
Eritrosit age can be determined with Fe-59, such as for transfusion needs to know the age of donor’s eritrosit age.
Radioactive substance also help human to diagnose some disease, so how is the manner? Radioisotope is injected to patient body (study in-vivo) although it is only reacted with blood, flank acid, or urine which is taken from patient body (study in-vitro). In study in- vivo, after radioisotope injected in patient body from mouth, injection, or implosive from nose, people are able to get information such an image or picture from an organ or a part of body patient with the assistance from SPECT (Single Photon Emission Computed Tomography) or PET (Positron Emission Tomography). Both instrument use gamma camera to detect gamma rays, besides it is also such some curve kinetic of radioisotope in an organ or a part of body. Also, those numbers describe radioisotope in an organ or a part of body.
In study in- vitro, the doctor takes some biological substance, such as 1mL of blood. The import quotation of biological substance is reacted with a substance that has been standardized with radioisotope. The detection is done with the assistance of gamma radiation that is stringing up with system instrumentation. That manner is well- known as non-imaging that commonly used to know the hormone uterus in patient blood, such as insulin and tyrosine. The data that is got from imaging or non-imagingtechnique gives information about an organ that is inspected.[7]
Some examples of radioisotopes which is used to diagnose and therapy some disease are in following table
No.
Radioisotopes
Half-life
Disintegration
Usage
1.
Au-198
2,69 days
Β
To control the function of kidney
2.
C-11
20,3 days
β and
To produce the image of brain and pancreas
3.
Fe-59
44,5 days
Β
To determine iron metabolism in blood
4.
Xe-133
5,25days
Β
To measure lungs capacity
5.
I-125
60 days
To determine the blood degree
6.
O-15
122 seconds
To examine the function of lungs
7.
Se-75
119 days
To determine the shape and measurement of pancreases



E.     The Negative impacts of Radioactive
Based on physics book, Radioactive also creates some impacts when it uses in different way, as follows:
1.      Hair: people hair is easy to be lost quickly when it gets radiation in 200 Rems or more, Rems is a squad of radioactive fervency.
2.      Brain: the cell of brain will be broken directly except it gets radiation in 5000 Rems or more,  Also heart, radiation assassinate nerve cell, blood vessel, then it cause of stiff and death in sudden.
3.      Thyroid gland: thyroid gland is really susceptible, radioactive Iodium in a specific amount a part or all thyroid gland.
4.      Blood circulation: When people get radiation for about 100 Rems, the amount of limfosit blood is decreased. Therefore the sacrifice is more susceptible to infection. The first symptom, such influenza. Based on the data, when the explosion occurring in Nagasaki and Hiroshima, exhibit symptom can hold out for about 10 years and big possibility it has some risks in long period, such as leukemia and limfoma.
5.      Heart: if heart gets radiation in 1000 to 5000 Rems will impact the detriment to blood vessel and heart fail and death in sudden.
6.      Digestion pipeline: radiation in 200 Rems will impact the detriment to intestine pipeline, and vomit, also queasy and diarrhea with blood.
7.      Reproduction pipeline: radiation will damage reproduction pipeline with fervency under 200 Rems. In long period, the sacrifice will be barren.
Commonly, when human gets danger nuclear radiation there will be gene mutation, because the changing of substance structure and chemistry reaction that damage people, plant, and animal cell. The impact of radioactive radiation creates direct character, such as: the increasing of heart and artery beat, headache, losing of desire to eat, diarrhea, fever. Nevertheless, it caused the weight lower, blood cancer, and leukemia.[8]












CHAPTER III
CLOSING
A.    CONCLUSION
1.      Radioactive is a chemical substance that is really useful for every aspect in life, such as agriculture, industry, biological especially human biological aspect.
2.      With radioactive, human is able to know the condition, function of an organ in people body. It also can detect and diagnose some disease that exists in people body by using X, gamma, beta, alpha rays.
3.      Radioactive is a substance that was invented Henry Becquerel, and it was continued Marie and Pieree Currie, and it consists of electron, proton, positron, beta ray, alpha ray, and gamma ray.
4.      Radioactive is a substance where it has atomic number more than 83, means it is including into unstable substance.
5.      Radioactive can be used when it has been disintegrated, so radioactive substance is dangerous when it is still unstable.
6.      Radioactive needs object to be used, such as human biological aspect.
7.      Radioactive gives negative impact for human biological aspect where people cannot use it in the wrong way, such as it is the cause of danger disease, people death, born abnormal baby, so on.
8.      Radioactive substance is able to break people cell easily.
9.      Radioactive is used for therapy some disease with the assistance of a tool named SPECT (Single Photon Emission Computed Tomography) or PET (Positron Emission Tomography).
10.  The usage of radioisotope as tracer is based on knot that radioisotope has chemistry character as a stable isotope, so radioisotope gets chemistry reaction as stable isotope.



B.     SUGGESTION
1.   Everyone must be able to differ between danger and useful substance, and change their thought about chemical substance, because not all chemical substance is danger, such as radioactive.
2.   The usage of gamma, beta, alpha, and X-ray may be good to know the condition, function of people organ. Also, to do therapy and diagnose some disease.
3.      A specialist doctor must be careful to use those rays in the right way.



[1]Alonso, M and Finn, E.D. 1980 Fundamental University Physics, page 134
[2]Siswanto, Sukaryadi. 2009 Fisika kelas 12 page 144
[3]Kanginan, Ir. Marten. 2007 Fisika, page 133
[4]Handayani, Sri. 2006 Biologi, page 06
[5]Browne, M.E. 1999. Teory and Problem of Physics for Engineering and Science, page 157
[6]Ibid
[7]Ibid page 5
[8]Ibid page 5


BIBLIOGRAPHY
Alonso, M and Finn, E.D. 1980 Fundamental University Physics
Siswanto, Sukaryadi. 2009 Fisika kelas 12
Kanginan, Ir. Marten. 2007 Fisika
Handayani, Sri. 2006 Biologi
 Sagan L. On the origin of mitosing cells. J Theor Biol 1967 Mar;14(3):255-74.
 Greenstein B, Greenstein A. Medical biochemistry at a glance. Oxford: Blackwell Sciences Ltd; 1996. p.3
Schatz G, Halsbrunner E, Tuppy H. Deoxyribonucleic acid associated with yeast mitochondria. Biochemical and biophysical research communication 1964;15:127-32.